ODCs

Click node...

1 OMIM reference -
2 associated genes
20 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 6

1 OMIM reference -
3 associated genes
25 signs/symptoms

Budd-Chiari syndrome

Polycythemia vera


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	JAK2	(0.66)	MPL

Citations in the biomedical literature:

Budd-Chiari syndrome		Polycythemia vera
	Synonym(s): (no synonyms)		Synonym(s): - Acquired primary erythocytosis - Erythremia - Osler-Vaquez disease - PV - Polycythemia rubra vera - Vaquez disease

	Classification (Orphanet): - Rare hepatic disease		Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease

	Classification (ICD10): - Diseases of the circulatory system -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: variable Average age of death: any age Type of inheritance: multigenic/multifactorial		Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: variable Average age of death: normal Type of inheritance: sporadic

	External references: 1 OMIM reference - 1 MeSH reference: D006502		External references: 1 OMIM reference - 1 MeSH reference: D011087


COMMON SIGNS	- Acute abdominal pain / colic - Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia - Hepatomegaly / liver enlargement (excluding storage disease) - Portal hypertension - Splenomegaly - Weight loss / loss of appetite / break in weight curve / general health alteration

Budd-Chiari syndrome		Polycythemia vera
	Very frequent - Ascitis Frequent - Abnormal hepatic enzymes / transaminases - Cirrhosis - Esophageal varices - Fever / chilling - Hepatocellular liver disease / hepatic failure Occasional - Acute hepatic failure - Acute ischemic syndrome - Biliary / gallbladder stones / lithiasis / cholecystitis - Hepatitis / icterus / cholestasis - Intestinal obstruction / ileus - Malabsorption / chronic diarrhea / steatorrhea - Mesenteric / intestinal infarction - Peritonitis / peritoneal abscess		Very frequent - Acute leukemia - Angor pectoris / myocardial infarction - Chronic arterial hypertension - Dizziness - Ecchymoses - Epistaxis / nose bleeding - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Facial pain / cephalalgia / migraine - Gingivorrhagia / gingival bleeding - Myelodysplastic syndrome - Tinnitus Frequent - Articular / joint pain / arthralgia - Asthenia / fatigue / weakness - Respiratory distress / dyspnea / respiratory failure / lung volume reduction Occasional - Arterial embolism / thrombosis - Claudication / pain on mastication / while chewing - Pruritus / itching - Transient cerebral ischemia / stroke - Venous thrombosis / phlebitis / thrombophlebitis